Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives
نویسندگان
چکیده
A simple protocol, involving the green synthesis for the construction of novel bis-pyrimidine derivatives, 3a-i and 4a-e are accomplished by the aqueous diethylamine media promoted tandem Aldol-Michael reaction between two molecules of barbituric acid derivatives 1a,b with various aldehydes. This efficient synthetic protocol using an economic and environmentally friendly reaction media with versatility and shorter reaction time provides bis-pyrimidine derivatives with high yields (88%-99%).
منابع مشابه
Correction: Al-Majid, A.M., et al., Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives. Int. J. Mol. Sci. 2013, 14, 23762–23773.
1 Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; E-Mails: [email protected] (A.M.A.-M.); [email protected] (H.J.A.-N.); [email protected] (Y.N.M.) 2 Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426-Ibrahimia, Alexandria 21321, Egypt 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King ...
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